PUBLIC MARKS with tags debugger & howto

I'm curious if anyone is using Zend Studio to debug local installations of drupal? I've been using Zennd for development purposes for a while but just decided to try and make it work locally allowing me to debug code without actuallly running it on my server. I managed to get the server up and running fine but can't seem to make it debug drupal. Any suggestions, tips, etc would be greatly appreciated. Please share your experiences with this product.